The first story of Paddington bear was published 50 years ago in 1958, after being found in London's Paddington train station, with a little tag around his next saying "Please look after this bear."   Paddington bear originally came from the Darkest Peru, and brought up by his Auntie Lucy, following himself becoming an orphan through an earthquake.  This all happened during his first few weeks of life, and his true name is Pastuso.

Aunty Lucy looked after Paddington bear until she retired, and went to live a retirement home in Lima; and she sent him to England to live.  Although she needed him to learn English before he stowed away on a boat.  After being found by the Brown family, by Mr Brown, in Paddington station, he was taken back to their home 32 Windsor Gardens to live with them.

So now in the house lives; Mr and Mrs Brown, their 2 children (Jonathan and Judy) and Mrs Bird their housekeeper.  Although he didn't know when his birthday was, the Brown family decided they would start over again and begin at one, and he celebrates two birthday (just like the Queen) on the 25th June and 25th December every year.

Paddington keeps in regular contact with his Aunty Lucy, via postcards.  In Windsor Court, Paddington bear has found a confidant; Mr Gruber, as he also has emigrated to England.  He owns a antique shop in Portobello Road, and Paddington bear visits a local bakery to buy some buns and then takes them to the shop to share with Mr Gruber, with a cup of coco for their elevenses.  Mr Gruber addresses Paddington bear always as "Mr Brown."  32 Windor Court is situated in the Notting Hill area of London, and is a semi-detached house, not to far from Portabello Road.  With the next door neighbour being Mr Curry, who is famous for going "bearrrrrrrrrrrr" who tries to take advantage of Paddington.

Paddington bear is an iconic image, with his red old brush hat (a hand down from his uncle in Peru.)  The Brown family first bought him a duffel blue coat, with wooden toggles and a hood. Wellington boots complete the outfit, also with his brown suitcase with his initials on the front, which holds a secret compartment.

His favourite food is marmalade (which I personally think is a bit gross lol, maybe thats just me lol?!), with a jar always being in his suitcase and a marmalade sandwich always being under his hat.  When he goes shopping he has a wicker shopping basket on wheels.  The most important possession he owns is his scrapbook,  where he documents all his adventures and all the postcards he receives from his Aunty Lucy.

I have grown up with Paddington bear, and even had a bear on my own, which I ironically left on a train :( I must buy a new one someday...I miss my bear :(

Só o comprei porque, na altura, andava um bocado com a mania de ver filmes do Quentin Tarantino . O meu objectivo era mesmo vê-los todos, mas como a vida não está fácil, apareceu-me este à frente e comprei-o. O filme fala-nos de um plano perfeito, que acabou por não ser assim tão perfeito. Tudo estava preparado para correr às mil maravilhas. O problema aqui é que eles não puseram na equação a instabilidade humana e a polícia. Sob pressão somos uma verdadeira caixinha de surpresas.

Joe Cabot (Lawrence Tierney) reúne seis estranhos, para executar o plano perfeito. Eles eram completos estranhos uns para os outros. A sua identificação só era conhecida por Cabot. Eles eram Mr. White (Harvey Keitel), Mr. Orange (Tim Roth), Mr. Blonde (Michael Madsen), Mr. Pink ( Steve Buscemi), Mr. Blue (Edward Bunker) e Mr. Brown (Quentin Tarantino). Eles iriam assaltar um joelharia, quando tudo corre mal. A polícia aparece de repente ! O grupo não aguenta a pressão e foge, morrendo Mr.Brown e deixando Mr.Orange às portas da morte. Mr.Blue desaparece no meio daquela confusão toda. É então que eles se reúnem num armazém. Que era o local de reencontro. Os intervenientes aqui serão Mr.White, Mr.Pink, Mr.Orange e Mr.Blonde. Imediatamente eles começam a suspeitar que existe um informador da polícia entre eles. Grande parte do filme é passado neste local. O filme também recorre a algumas analepses (ao estilo de Lost), para mostrar como é que eles entraram para o gangue.

Com tudo isto eles começam a desconfiar uns dos outros. É esta desconfiança, que irá criar um ambiente de grande tensão naquele armazém. Toda a gente desconfia de alguém. É através de deduções que Mr.White e Mr.Pink tentam chegar ao informador, por outro lado também existe a possibilidade de não existir qualquer informador e apenas terem tido grande azar. O final torna-se um verdadeiro pandemonium. Bem ao estilo do velho oeste. O filme é surpreendentemente bom, sinceramente gostei de ele todo. Tanto as partes de humor, como as falas, como também todo o ambiente de "cortar à faca". O final não poderia ser melhor. Quem é o informador ? O que é que vai acontecer dentro daquele armazém ? Isso são as perguntas que nos irão pôr colados ao ecran até ao fim.

Floyd Brown, the man behind such slander as the infamous Willy Horton ads is back and as immoral as ever. This time he's turning his attacks, on Barack Obama. The race-baiter extraordinaire drew upon racism in this ad just as he did in the Willy Horton ads in the 1980s. The ad repeats the false claim that Barack Obama was a Muslim as a child(which he wasn't.) It then says that it doesn't matter if he was a Muslim then(which again he wasn't) what matters is if he is one now(which he's not.)

Every Republican should denounce this racist and xenophobic ad for the trash that it is. However, the majority won't. A few with a conscience may, but most won't. Most will simply say that this is politics as usual and say that the use of racism, xenophobia, and slander in a political campaign is perfectly acceptable. It has been but that doesn't mean it should be. We're Americans, we should be better than this. We should run campaigns where all involved take the high road and deal solely in the facts rather than make up lies which they can use to scare the ignorant. He and every involved on this ad or the Willy Horton ad(including Roger Ailes) should be ashamed of themselves.

Anyone who had morals or a conscience would be outraged, but clearly Brown doesn't have that burden. McCain also apparently doesn't as he has resigned himself to silence on the misconduct of his party and its attack dogs.

Num mundo onde todo mundo tenta tirar vantagem é sempre bom divulgar firmas que fazem o serviço honesto.

Meu carro apresentou problemas no ar condicionado. Do nada parava de funcionar e do nada voltava a funcionar.

Levei o carro numa famosa loja de ar condicionado em Botafogo. Verificaram que não foi vazamento do gás, olha daqui, olha dali e vem o diagnóstico. Condensador condenado. Tem que trocar tudo. Orçamento R$ 4 mil !!!!!

Claro que nem fiz. Lembrei-me então da indicação do mecânico do meu pai. É uma pequena loja, na rua que passa em baixo da Linha Vermelha. Mr Brow !!!!

Mesmo procedimento. Olha daqui, olha dali. Relatando o problema, o mecânico, que esqueci o nome, tem uma idéia do que seja. Deixo meu carro lá e orçamento: R$ 50 !!!

Era uma pequena peça de plástico que queimou e com isso ficava com mal contato.

Serviço feito e passado três meses, o ar funciona normalmente !!!!

Isso mesmo queriam me cobrar R$ 4 mil por um serviço que foi feito por R$ 50 ....Se tiverem problemas com ar condicionado dos seus carros ... recomendo a Mr. Brown.

Mr. Brown Acessórios para Veículos

R. Bela, 493, Fundos - São Cristovão - Rio de Janeiro
(21)2580-7736

Spring News letter of Faustman spring 2008 newsltr

Sooner than expected, some have already found the posting of Phase one trials with Denise Faustmann. Phase one is more for the FDA, they seem to be treating this findings as a new drug! They are being overly cautious. BCG has been administered to people who were diagnosed with Malaria for over twenty years so this Phase one seems almost useless, but according to FDA standarts it must be done for new drugs. Humm wonder why it needs to be done in this case?? Any ideas anyone?
ALSO please, i understand why your hopes are not too high, but lets see here, lets call this the most promising cure of all time. The BCG may not be the ultimate answer but the development of the known findings will help to know and overcome the illness of many non regenerative (can I say That? Shouldn't was past thinking) cells. Which we know now the are all regenerative in tissue form but the missing elements are reasons for it.

Here are a few links,
http://www.clinicaltrial.gov/ct2/show/NCT00607230
http://medicalusers.com/phase-i-diabetes-trial-iniated-by-massachusetts-general-hospital/
http://threeyearsfree.blogspot.com/2008/03/its-here.html
http://www.bernardfarrell.com/blog/2008/03/type-1-cure-trials-start.htm

--
If God promises something, then faith must fight a long and bitter fight

For a person with chronic diabetes, life can be a gruelling battle to keep blood sugar levels close to normal. Scientific discoveries may prove vital.

Please help fund the mission of "The Cure" and for all those that currently have Diabetes or even those that may get it!
I am currently involved with Human trials for "the Cure" with Denise Faustmann in Boston Mass.
Denise Faustman, is a U.S. physician and medical researcher. An associate Professor of Medicine at Harvard University, her work specializes in Diabetes mellitus type 1 (formerly called juvenile diabetes). She has worked at Massachusetts General Hospital in Boston since 1985.

NEWS!

http://www.boston.com/news/health/articles/2008/03/03/a_history_of_being_innovative_and_fun/

On Mon. August the 04 is my next trip and again I am still seeking anyone who wishes to;
- come along to give blood
- Help to cover some costs
- or even advise oh doing this in a less costly fashion too!
Currently travel is taking a Big chunk of my monies [AND I also need someone to go down with me!]
Look at it this way Help to find the best possible cure!!
See more about the development and research......

Faustman's research is based on the observation that autoreactive T cells, that is, T cells programmed to attack the body's own cells and tissues, are more sensitive to the effects of TNF-alpha (TNF-α), a cytokine that influences the immune system. TNF-α is a strong promoter of inflammation, and several treatments have been developed to block the effects of TNF-α in chronic and autoimmune diseases, including adalimumab, infliximab, and entanercept. However, side effects of these drugs include flare-ups of autoimmune symptoms.

Under some conditions, TNF-α causes T cells to undergo apoptosis, or programmed cell death. Autoimmune T cells are more sensitive to TNF-α and undergo apoptosis more readily than normal T cells when exposed to TNF-α. Faustman's hypothesis, somewhat contrary to conventional thinking, is that blocking TNF-α actually promotes the survival of undersirable autoreactive T cells, and that autoimmune diseases should be treated by stimulating TNF-α to trigger apoptosis in self-destructive autoimmune T cells. [1]

Former Chrysler chairman Lee Iacocca, whose wife died of type-1 diabetes complications and who has declared a desire to see the disease cured in his lifetime, is a patron of her work. After Faustman was denied funding by the JDRF, The Iacocca Foundation provided an $11.5 million dollar grant which both supported Faustman's work, and is being used for a clinical trial to be conducted by Harvard researcher David Nathan. This trial will not use spleen cells but only bacillus Calmette-Guerin (BCG), a weakened strain of bacteria that is used in the prevention of tuberculosis and in the treatment of bladder tumors and bladder cancer. BCG induces TNF-α. In previous human trials, it has not been shown to have a therapeutic effect in type 1 diabetics. Faustman hypothesizes that the correct dosing of BCG for diabetics has not been utilized in previous trials. As part of her research, she is seeking to define a dose that might have a therapeutic effect in the clinical trial to be led by Dr. Nathan.

Faustman's research has been profiled in the New York Times on November 9, 2004 and March 24, 2006, and in the Wall Street Journal on March 24, 2006.
Type 1 Autoimmune Diabetes is caused by rogue T cells that attack healthy tissue. In the case of Type 1 Autoimmune Diabetes, the healthy tissue under attack are the beta cells that regulate and produce insulin. Faustman's protocol of Freund's adjuvant, along with the spleen cells, was effective in curing even mice with end-stage diabetes. In her human trial, scheduled for early 2008, she plans to use BCG to kill the rogue T-cells that maintain the diseased state of autoimmunity. CFA and BCG affect rogue T-cells in a peculiar way, they induce cell apoptosis, a kind of cell suicide. Normal T-cells remain unaffected. The research is promising because it is hoped that once the bad T-cells are gone, regeneration of the beta cells will ensue. However, a debate continues over the source of the islet cell regeneration.

http://www.news.harvard.edu/gazette/2001/07.19/01-stemcells.html
That was the beginning but now it is even easier!!!
http://www.cureautoimmunity.org/research-bcg%20humans%20mice.htm

• Gina Kolata. "A Controversial Therapy for Diabetes Is Verified", The New York Times, March 24, 2006. Retrieved on 2007-08-17.

• Gina Kolata. "I Beg To Differ: A Diabetes Researcher Forges Her Own Path to a Cure", The New York Times, November 9, 2004. Retrieved on 2007-08-17.

• [6] Massachussetts General Hospital Diabetes Update Page

• [7] Wall Street Journal article, "After Initial Rejection, Scientists Back Work on Diabetes

• [8] Faustmanlab.org - home page regarding this research with updates and new information A smal PDF best read with,
  

• Join Lee Now

I need your help keeping my promise.

Up until 2004, my family had never asked the public for help in raising money for cure research. When we finally did so with our JoinLeeNow campaign, it was an incredible success, raising more than $11 million for breakthrough regeneration research. Now, as we work to build upon those findings and look to support even more aggressive initiatives, I'm once again looking to generous individuals like you.

With what we know now, so much is possible. Imagine being able to stop the autoimmune attack long enough so the natural process of regeneration can make the need for insulin injections non-existent.... imagine if we had a viable, cost-effective alternative to immune suppression... and imagine if we could apply the diabetes cure we've found for afflicted mice to humans.

The fact of the matter is, what has long been my dream - and one I share with millions of others - is not far from becoming our reality. But if I'm to keep my promise of seeing this fight through to the end, it's going to be because of the public's continued support. So whether you've given in the past or have just learned of The Iacocca Foundation, I urge you to make a donation today. As you well know, finding a cure for this terrible disease simply couldn't be any more important.

With my sincere thanks,

Lee





http://www.iacoccafoundation.org/fundraising.html

• [9] "Putting Up With Self" from Scientific American

• [10]Diabetes Health article on Dr. Faustman

• [11]Effect of BCG in Humans and Mice

• [12]Bacillus Calmette-Guerin (BCG) Vaccine

http://www.massgeneral.org/diabetes/laboratory_type1.htm

Researchers say they may be on to a promising way to cure Type 1 diabetes in mice: stop the immune system before it kills off all the insulin-producing cells in the pancreas.
http://www.dallasnews.com/sharedcontent/dws/news/healthscience/stories/032406dnnatdiabetes.e29a92.html
Either way, the result of the studies opens up a new route for diabetes therapy, Chong said, showing that "a diabetic mouse, even as an adult, has an ability to make new insulin-producing cells.
http://ww3.komotv.com/Global/story.asp?S=4674587
http://www.nytimes.com/2006/03/24/health/24diabetes.html?ex=1300856400&en=b3101dda7b44858c&ei=5088&partner=rssnyt&emc=rss

Your asking why I am doing this?? cuz Insulin injections for each time I eat are no longer allowing control!! Plus I take an additional two injections to help [so they say] maintain control!! BAH!

Thousands of Diabetics Report Adverse Effects from GE Insulin

Remember how safe and well tested GE products are? Well try these:

1.Real Video: Watch Fox TV investigation into claimed deaths from GE
'Humalin' at:

IT IS TOO BAD THIS IN A REALPLAYER ONLY FILE> REALPLAYER = BADWARE but this may help you so much better,

Real Alternative will allow you to play RealMedia files without having to install RealPlayer. All RealMedia formats
http://members.tripod.com/diabetics_world/movies/fox13-2-12a.ram

2. More material at:
http://members.tripod.com/diabetics_world/fox131.htm

Why should we believe anyone from the genetic engineering industry? It's no
different to the tobacco industry.

This is to say nothing of the regulatory authorities who are implicated in
this: see Canadian Class Action below.

'It was a decision which said to me, 'You are going to be using this
insulin - you are going to be involved in the fight of your life.' And
that's what's happened'. Colleen Fuller, Candian GE insulin litigant (see
reports below)

NATURAL LAW PARTY WESSEX
http://www.organicconsumers.org/patent/geinsulinbad.cfm

So now you may know more that an average diabetic, I am asking for someone who could provide Blood and Travel with me to Boston. *or* assistance with the travel costs to get there.
The cheapest way and almost easiest is with JetBlue Airlines out of Buffalo.
The Bus system I took once and it is way to time consuming and the New York stop is unbearable!
Driving is almost the same cost to get there If you wish to not sleep:)
The costs of travel is just over $200 if you spend one day 04 - 18:00 or three days on an inefficient bus system!

It is very hard to believe that so many would partake in such a selfish way to which funds can assist may in such a much larger grand scale of things!!

Newly found may not be new but is to me after looking our own canadians are involved too!

U of A terminates diabetes researcher
Investigation uncovers 'financial irregularities'
Jodie Sinnema, The Edmonton Journal
Published: Friday, November 03, 2006
EDMONTON - The University of Alberta has terminated the employment of one of the chief researchers and doctors who headed up the internationally heralded diabetes project known as the Edmonton Protocol. Dr. Jonathan Lakey, who worked with friend and world-class surgeon Dr. James Shapiro, was terminated Thursday as a professor of surgery and university researcher.
An internal investigation discovered "financial irregularities related to his work with a third party," University Provost Carl Amrhein said, reading from a statement.
"I am writing to inform you that Dr. Jonathan Lakey has been terminated by the University of Alberta effective immediately," Amrhein wrote in a letter sent to about 15 staff members at Lakey's university labs.
"Dr. Lakey has made full restitution in relationship to the financial irregularities and has decided to pursue a counselling program aimed at addressing the circumstances that gave rise to the financial issues."
Amrhein said confidentiality rules prevent him from revealing how much money was involved, where it came from or why Lakey made the choices he did.
But he said the diabetes research projects will carry on with business as usual.
"There has been no suggestion whatsoever that research was affected, that research funds were involved or that any patient care was compromised," Amrhein said.
Lakey was one of the principal forces behind the development of an islet-cell transplantation procedure to treat patients with severe Type 1 diabetes. In 2000, the Edmonton Protocol made headlines around the world as the first medical treatment that enabled diabetics to get off insulin.
Since then, subsequent research has found the treatment wears off over time, but is still useful with some strains of the disease.
Lakey worked closely with Dr. James Shapiro, a transplant surgeon of international repute and Lakey's friend.
Lakey harvested the islet cells from cadavers while Shapiro did the surgeries.
In December 2005, a Journal story reported that Shapiro, Lakey and their team had more than $45 million in research grants.
At that time, Lakey and Shapiro supervised 40 staff members, many of them researchers.
While Lakey's research position is now ended, he remains on paid leave with Capital Health.
The health authority is conducting its own investigation to determine if Lakey should also be terminated from his jobs as technical director of the Comprehensive Tissue Centre -- which processes corneas, skin, bones and heart valves for transplant -- and as director of the Clinical Islet Isolation Laboratory at the University of Alberta hospital.
Steve Buick, spokesman for Capital Health, said the investigation should wrap up next week and a personnel decision should be made soon.
"There will be no impact on patient services," Buick said. Since early September, when Lakey began his paid leave, Dr. David Ross has been heading the tissue centre and Shapiro has been in charge of the islet lab.
Amrhein said the university has yet to determine who will take over Lakey's roles on campus. Dr. Tom Marrie, the dean of medicine, will be working with Lakey's graduate students to determine who will supervise them, Amrhein said.
Investigation uncovers 'financial irregularities'
Jodie Sinnema, The Edmonton Journal
Published: Friday, November 03, 2006
"I have complete and total confidence in the dean and the principal (scientists) involved in the diabetes research and our colleagues at Capital Health," he said.
"The primary concern for me is for Dr. Lakey as an individual and I think it is encouraging he has decided to pursue a counselling program."
David Johnson, president of the Association of Academic Staff at the U of A, said he believes Lakey will stay in Edmonton to receive counselling. Johnson wouldn't offer details on how Lakey is faring.
Calls to Lakey's office and home went unanswered Thursday. His legal adviser also could not be reached for comment.
Johnson said his association is satisfied the university followed all the guidelines during the investigation process. He said Lakey hasn't spoken about launching a wrongful dismissal case or about searching for another job.
jsinnema@thejournal.canwest.com

• http://www.canada.com/edmontonjournal/news/story.html?id=5d706040-bac3-4a74-b923-8c4278d5cb47

The New York Times reported an internal audit at the Juvenile Diabetes Research Foundation (JDRF) discovered two men had squandered hundreds of thousands of dollars from the non-profit organization.

The two men responsible, Jonathan Stenger, national director, and Jason Brown, national manager, were dismissed late last year. Here are a few choice words for these men, in light of their insulting embezzlement. Families, friends and loved ones raised these funds to research and cure Type 1 diabetes. Shame on you! Or am I missing the Robinhood moral of this murky story? Please let these men know how you feel about their cavalier misuse of funds. Do they not know what life with diabetes is like?

There's no excuse. In fact, I cannot stretch my imagination far enough for their irreverent and smug use of fund raising dollars. Mr. Stenger and Mr. Brown had submitted counterfeit receipts into the computer system of JDRF to protect their illicit sweepstakes - for whatever in the world they were doing.

Thankfully a JDRF internal audit discovered their inappropriate indulgence - unfortunately, the discovery came five years after it all began.

Mr. Stenger and Mr. Brown have a lot of explaining to do. Then again, no amount of explaining (or funding) has cured Type 1 diabetes. Will this be any different?

• New York Times article, Nonprofit Diabetes Group Is Subject of Investigation
• Amy Tenderich's response to the New York Times article, Scandal at JDRF!

People must have righteous principals in the first,
and then they will not fail to perform virtuous actions.

Martin Luther

And below are the lyrics

I wonder if you know,
How they live in Ang Mo Kio
Go to city many gantry
Can’t afford your speed too low
Fast and furious! (Kena!) (beep! beep! beep!)
Slow is dangerous (Aiyah!) (beep! beep! beep!)

I wonder if you know,
How they live in Toa Payoh
Please lah tolong, only Lorong
Not Expressway also tio!
Fast and furious! (Kena!) (beep! beep! beep!)
Spread like virius! (Aiyah!) (beep! beep! beep!)

Many many taxes danglin
ERP now is randomin
Keep your speed ‘bove 45
Or everybody Cashcard won’t survive!
Suka suka ERP on
Happy happy gantry can born
16 new ways to gope your lui
See already want to pui!

Gahmen say take MRT
Cos car is only luxury
Build the road for Fellari
Normal car will up lorry
Ji Pa Ban (uh!), Ichiban (uh)
No million dollars you Lan Lan
CTE is the place to be
Singapore road for VIP

I wonder if you know,
How they live in Ang Mo Kio
Reach work early, at 5.30
Spend three hours drink teh-o
Can’t be seraious! (wah lau!) (beep! beep! beep!)
Live like vampires (ouch!) (beep! beep! beep!)

I wonder if you know,
Where the gantry never grow
Where the lorry Never worry
Travel freely where you go
Pulau Bukom! (Don’t have!) (beep! beep! beep!)
Pulau Tekong (Huat ah!) (beep! beep! beep!)