Blogs about: Dna Damage Repair
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AGEs linked to DNA damage in diabetes
A new and as-yet-unpublished study proposes a causative link between advanced glycation endproducts (AGEs) and DNA damage, potentially explaining the link between diabetes (where frequent blood glucos… more »
Ouroboros
AGEs linked to DNA damage in diabetes
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ouroboros wrote 1 week ago: A new and as-yet-unpublished study proposes a causative link between advanced glycation endproducts … more »
DNA double-strand breaks and aging
ouroboros wrote 1 month ago: Do DNA double-strand breaks (DSBs) have anything to do with aging? We have some reason to believe t … more »
A glutamine a day keeps senescence away
ouroboros wrote 2 months ago: Cellular senescence is regarded as a tumor suppressor mechanism: damaged cells permanently leave the … more »
DBC1 stimulates p53 by inhibiting SIRT1
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ouroboros wrote 3 months ago: SIRT1, the most widely studied of the protein family known as sirtuins, is a histone deacetylase tha … more »
Histone H1 in aging immune cells
ouroboros wrote 4 months ago: From Happel et al., a detailed characterization of histone H1 profiles in peripheral blood lymphocyt … more »
You are what you(r mom) eats
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ouroboros wrote 4 months ago: Gestational protein restriction (i.e., limiting the intake of a pregnant female) has a powerful infl … more »
Natural products that fight molecular aging
ouroboros wrote 5 months ago: Skin wrinkling, one of the most conspicuous signs of aging, is the result of breakdown of structural … more »
Longevity mutation suppresses genome instability
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ouroboros wrote 6 months ago: Earlier this week we learned that mutations in the kinase SCH9, combined with intervention in the RA … more »
Hyperactive p53 and premature aging
ouroboros wrote 6 months ago: Late last year we learned that the p53 tumor suppressor response to DNA damage dwindles with age, po … more »
p53 decline in old age: a cause of late-life cancer?
ouroboros wrote 7 months ago: The p53 protein is one of the principal defenses against tumorigenesis. It integrates upstream signa … more »
In the heart but not the blood: Transcriptional robustness in the aging hematopoietic system
ouroboros wrote 9 months ago: Last year we learned (mostly from the Vijg lab) that aging in the heart is associated with a dramati … more »
Replication stress vs. lifespan, across evolution
ouroboros wrote 9 months ago: Replication stress, defined as the harmful effects of partially replicated DNA persisting in the nuc … more »
Two wrongs make a right? Improving survival by combining mutations in mismatch repair and telomere maintenance
ouroboros wrote 9 months ago: In mice, telomerase deficiency results in a segmental progeria that increases in intensity over the … more »
Conference report: SENS3
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Oki wrote 10 months ago: Okie here, back from the SENS3 conference in Cambridge, and slowly recovering from jet lag. General … more »
'The common biology of cancer and aging'
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ouroboros wrote 11 months ago: In yesterday’s issue of Nature, Toren Finkel, Manuel Serrano and Maria Blasco (the latter two … more »
A flowchart of the molecular events of aging
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ouroboros wrote 11 months ago: On the web site of the aptly named pre-product biogerontology startup Legendary Pharmaceuticals, com … more »
Too tired to fix it: Declining DNA repair deficiency and energy budget in aging cells
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ouroboros wrote 1 year ago: Last week, we learned that DNA damage accumulates in aging hematopoietic stem cells (hSCs; see our e … more »
Nature Insight: DNA replication and repair
ouroboros wrote 1 year ago: Nature’s most recent “Insight” section is devoted to DNA replication, damage, and … more »
Sucking the life out of marrow: DNA damage accumulation in aged hematopoietic stem cells
ouroboros wrote 1 year ago: As we age, our organs gradually lose their ability to maintain constant levels of function, either i … more »
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